Pub. Date : 2020 Nov
PMID : 32461634
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2) or the increase of endogenous H2O2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 2 | Intracerebroventricular (icv) injection of hydrogen peroxide (H2O2) or the increase of endogenous H2O2 centrally produced by catalase inhibition with 3-amino-1,2,4-triazole (ATZ) injected icv reduces the pressor responses to central angiotensin II (ANG II) in normotensive rats. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 3 | In freely moving rats, H2O2 (5 mumol/1 mul) or ATZ (5 nmol/1 mul) icv reduced the pressor responses to ANG II (50 ng/1 microl) icv in SHRs (11 +- 3 and 17 +- 4 mmHg, respectively, vs. 35 +- 6 mmHg) and 2K1C hypertensive rats (3 +- 1 and 16 +- 3 mmHg, respectively, vs. 26 +- 2 mmHg). | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 4 | ATZ (3.6 mmol/kg of body weight) iv alone or combined with H2O2 icv also reduced icv ANG II-induced pressor response in SHRs and 2K1C hypertensive rats. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |
| 5 | The results suggest that exogenous or endogenous H2O2 acting centrally produces anti-hypertensive effects impairing central pressor mechanisms activated by ANG II in SHRs or 2K1C hypertensive rats. | Hydrogen Peroxide | angiotensinogen | Rattus norvegicus |