Pub. Date : 2020 Aug
PMID : 32461113
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Shikonin suppresses trophoblast cell growth via regulation of GLI1, and p62 mediated caspase 8activation. | shikonin | nucleoporin 62 | Homo sapiens |
| 2 | Shikonin blocked autophagic flux and promoted p62 interaction with caspase 8, resulting in caspase 8 activation. | shikonin | nucleoporin 62 | Homo sapiens |
| 3 | In conclusion, shikonin suppressed trophoblast cell growth by silencing GLI1 and increasing p62 co-mediated activation of caspase 8, which suggested a potential novel therapeutic target for UEP. | shikonin | nucleoporin 62 | Homo sapiens |