Title : The inefficacy of donepezil on glycated-AChE inhibition: Binding affinity, complex stability and mechanism.

Pub. Date : 2020 Oct 1

PMID : 32454110






1 Functional Relationships(s)
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1 It is suggested that glycation of lysine residues on the structure of AChE could change the conformation of the active site (Trp-86 and His-447) in a way that the orientation of acetylcholine interrupted. Histidine acetylcholinesterase (Cartwright blood group) Homo sapiens