Title : Diphenyl diselenide protects a Caenorhabditis elegans model for Huntington's disease by activation of the antioxidant pathway and a decrease in protein aggregation.

Pub. Date : 2020 Jul 22

PMID : 32453327






1 Functional Relationships(s)
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1 The mechanism proposed is the activation of DAF-16, HSP-16.2 and SOD-3 in whole body tissues to increase the antioxidant capacity and regulation of proteostasis, decreasing PolyQ aggregation and toxicity and reducing ROS levels, leading to an increase in lifespan, and healthspan. polyglutamine Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans