Pub. Date : 2020 Jul
PMID : 32452918
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. | Uric Acid | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. | Uric Acid | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Despite these conflicting views, several studies support the idea that hyperuricemia is indeed a cause of progression of kidney disease, with a putative role for soluble uric acid in activating renal NLRP3 inflammasome, in reprograming renal and immune cell metabolism and, therefore, in promoting kidney inflammation/injury. | Uric Acid | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | SUMMARY: Therapies aiming to decrease uric acid levels prevent renal NLRP3 inflammasome activation and exert renoprotective effects in experimental kidney diseases. | Uric Acid | NLR family pyrin domain containing 3 | Homo sapiens |