Title : High Doses of Drugs Extensively Metabolized by CYP3A4 Were Needed to Reach Therapeutic Concentrations in Two Patients Taking Inducers.

Pub. Date : 2020 Apr - Jun

PMID : 32446424






1 Functional Relationships(s)
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1 The high activity of the CYP3A4 isoenzyme was manifested by fast metabolism for quetiapine and diazepam, which took more than 1 year to normalize after the inducer, phenytoin, was stopped. Quetiapine Fumarate cytochrome P450 family 3 subfamily A member 4 Homo sapiens