Title : Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis.

Pub. Date : 2020 May 22

PMID : 32441256






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Specific deletion of the major PGE2 producing enzyme cyclooxygenase 2 (COX2) in osteoblasts or PGE2 receptor EP4 in peripheral nerve markedly ameliorates OA symptoms. Dinoprostone prostaglandin-endoperoxide synthase 2 Mus musculus
2 Specific deletion of the major PGE2 producing enzyme cyclooxygenase 2 (COX2) in osteoblasts or PGE2 receptor EP4 in peripheral nerve markedly ameliorates OA symptoms. Dinoprostone prostaglandin-endoperoxide synthase 2 Mus musculus