Pub. Date : 2020 May 15
PMID : 32429320
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rigosertib, via reactive oxygen species (ROS), stimulates cJun N-terminal kinases 1/2 (JNK1/2), which inactivate RAS/RAF signaling and thereby inhibit growth and survival of tumor cells. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Rigosertib, via reactive oxygen species (ROS), stimulates cJun N-terminal kinases 1/2 (JNK1/2), which inactivate RAS/RAF signaling and thereby inhibit growth and survival of tumor cells. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Rigosertib, via reactive oxygen species (ROS), stimulates cJun N-terminal kinases 1/2 (JNK1/2), which inactivate RAS/RAF signaling and thereby inhibit growth and survival of tumor cells. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Rigosertib, via reactive oxygen species (ROS), stimulates cJun N-terminal kinases 1/2 (JNK1/2), which inactivate RAS/RAF signaling and thereby inhibit growth and survival of tumor cells. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | JNK1/2 are not only regulated by ROS-they in turn can also control ROS production. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | JNK1/2 are not only regulated by ROS-they in turn can also control ROS production. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Here, we provide evidence that establishes p66Shc, an oxidoreductase, as a JNK1/2 effector downstream of Rigosertib-induced ROS production, DNA damage, and cell death. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |