Title : Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation.

Pub. Date : 2020 May 18

PMID : 32424160






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation. polyglutamine DnaJ heat shock protein family (Hsp40) member B6 Homo sapiens
2 These results demonstrate that the DNAJ proteins DNAJA1 and DNAJB6 can modulate polyQ aggregation in opposite manners, and thus that fine-tuning the cellular levels of DNAJ proteins is critical for suppression of polyQ aggregation and cell survival. polyglutamine DnaJ heat shock protein family (Hsp40) member B6 Homo sapiens
3 These results demonstrate that the DNAJ proteins DNAJA1 and DNAJB6 can modulate polyQ aggregation in opposite manners, and thus that fine-tuning the cellular levels of DNAJ proteins is critical for suppression of polyQ aggregation and cell survival. polyglutamine DnaJ heat shock protein family (Hsp40) member B6 Homo sapiens
4 These results demonstrate that the DNAJ proteins DNAJA1 and DNAJB6 can modulate polyQ aggregation in opposite manners, and thus that fine-tuning the cellular levels of DNAJ proteins is critical for suppression of polyQ aggregation and cell survival. polyglutamine DnaJ heat shock protein family (Hsp40) member B6 Homo sapiens