Title : The Roles of Endoplasmic Reticulum in NLRP3 Inflammasome Activation.

Pub. Date : 2020 May 14

PMID : 32423023






1 Functional Relationships(s)
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1 The NLRP3 (nucleotide-binding domain, leucine-rich-repeat-containing family, pyrin domain-containing 3) inflammasome senses pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs), and activates caspase-1, which provokes release of proinflammatory cytokines such as interleukin-1beta (IL-1beta) and IL-18 as well as pyroptosis to engage in innate immune defense. Leucine interleukin 1 alpha Homo sapiens