Title : Statins activate the NLRP3 inflammasome and impair insulin signaling via p38 and mTOR.

Pub. Date : 2020 Jul 1

PMID : 32421368






2 Functional Relationships(s)
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1 We found that mTORC1 inhibition with low doses of rapamycin (2, 20 nM) lowered macrophage priming of IL-1b mRNA and secretion of IL-1b caused by multiple statins. Sirolimus interleukin 1 beta Mus musculus
2 We found that mTORC1 inhibition with low doses of rapamycin (2, 20 nM) lowered macrophage priming of IL-1b mRNA and secretion of IL-1b caused by multiple statins. Sirolimus interleukin 1 beta Mus musculus