Pub. Date : 2020 Aug
PMID : 32385545
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | Specifically, CYP2C9 and CYP2A6 are the main enzymes responsible for VPA metabolism. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | However, the correlation between plasma VPA concentrations and CYP2C9 and CYP2A6 gene variations is uncertain. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | This meta-analysis aimed to investigate the relationship between CYP2C9 and CYP2A6 variants and plasma concentrations of VPA. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | We found that CYP2C9*3 was associated with standardized plasma VPA concentration; *3 allele carriers had a 0.70-mug/mL higher concentration per mg/kg than non-carriers (95% CI 0.25, 1.15; P = 0.002). | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 6 | CONCLUSION: This meta-analysis demonstrated that CYP2C9*3 and CYP2A6*4 genetic variants affect plasma VPA concentrations. | Valproic Acid | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |