Title : Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia.

Pub. Date : 2020 May 20

PMID : 32385093






2 Functional Relationships(s)
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1 Here we analyze male and female mice and show that HBCs also are activated with increasing age as well as non-cell-autonomously by increased expression of the retinoic acid-degrading enzyme CYP26B1. Tretinoin cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus
2 Odor/air stimulates CYP26B1 expression in olfactory sensory neurons mainly located in the dorsomedial OE, which is spatially inverse to ventrolateral constitutive expression of the retinoic acid-synthesizing enzyme (RALDH1) in supporting cells. Tretinoin cytochrome P450, family 26, subfamily b, polypeptide 1 Mus musculus