Title : Biotin, coenzyme Q10, and their combination ameliorate aluminium chloride-induced Alzheimer's disease via attenuating neuroinflammation and improving brain insulin signaling.

Pub. Date : 2020 May 8

PMID : 32383521






2 Functional Relationships(s)
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1 AlCl3 resulted in impaired memory, significant increase in Abeta, lipid peroxides, inflammatory markers, caspase-3, and pSer-IRS-1, with significant reduction of the antioxidants, pTyr-IRS-1, and p-Akt reflecting Abeta-induced inflammation and defective insulin signaling. Aluminum Chloride amyloid beta precursor protein Homo sapiens
2 AlCl3 resulted in impaired memory, significant increase in Abeta, lipid peroxides, inflammatory markers, caspase-3, and pSer-IRS-1, with significant reduction of the antioxidants, pTyr-IRS-1, and p-Akt reflecting Abeta-induced inflammation and defective insulin signaling. Aluminum Chloride amyloid beta precursor protein Homo sapiens