Title : Deferoxamine Ameliorates Compressed Spinal Cord Injury by Promoting Neovascularization in Rats.

Pub. Date : 2020 Sep

PMID : 32383023






2 Functional Relationships(s)
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1 Using an SCI model of moderate compression, rats were intraperitoneally injected with 30 mg/kg or 100 mg/kg DFO for 1-2 weeks, and significant neovascularization was found in the injured spinal cord, showing overexpression of hypoxia inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF), and an increase in the number of new blood vessels. Deferoxamine hypoxia inducible factor 1 subunit alpha Rattus norvegicus
2 Using an SCI model of moderate compression, rats were intraperitoneally injected with 30 mg/kg or 100 mg/kg DFO for 1-2 weeks, and significant neovascularization was found in the injured spinal cord, showing overexpression of hypoxia inducible factor-1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF), and an increase in the number of new blood vessels. Deferoxamine hypoxia inducible factor 1 subunit alpha Rattus norvegicus