Title : WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2.

Pub. Date : 2020 May 7

PMID : 32382056






5 Functional Relationships(s)
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1 The activity of human paraoxonase 2 (PON2) is rapidly reduced in cells incubated with the bacterial quorormone 3-Oxo-dodecanoyl Homoserine Lactone (3OC12HSL), an observation that led to hypothesize a fast PON2 post-translational modification (PTM). N-(3-oxododecanoyl)homoserine lactone paraoxonase 2 Homo sapiens
2 The activity of human paraoxonase 2 (PON2) is rapidly reduced in cells incubated with the bacterial quorormone 3-Oxo-dodecanoyl Homoserine Lactone (3OC12HSL), an observation that led to hypothesize a fast PON2 post-translational modification (PTM). N-(3-oxododecanoyl)homoserine lactone paraoxonase 2 Homo sapiens
3 The activity of human paraoxonase 2 (PON2) is rapidly reduced in cells incubated with the bacterial quorormone 3-Oxo-dodecanoyl Homoserine Lactone (3OC12HSL), an observation that led to hypothesize a fast PON2 post-translational modification (PTM). N-(3-oxododecanoyl)homoserine lactone paraoxonase 2 Homo sapiens
4 Recently, we detected a 3OC12HSL-induced PTM in a cell-free system in which a crude extract from 3OC12HSL-treated HeLa cells was able to inactivate and ubiquitinate at position 144 a recombinant PON2. N-(3-oxododecanoyl)homoserine lactone paraoxonase 2 Homo sapiens
5 Recently, we detected a 3OC12HSL-induced PTM in a cell-free system in which a crude extract from 3OC12HSL-treated HeLa cells was able to inactivate and ubiquitinate at position 144 a recombinant PON2. N-(3-oxododecanoyl)homoserine lactone paraoxonase 2 Homo sapiens