Title : CDDO-Me Inhibits Microglial Activation and Monocyte Infiltration by Abrogating NFκB- and p38 MAPK-Mediated Signaling Pathways Following Status Epilepticus.

Pub. Date : 2020 May 1

PMID : 32370011






3 Functional Relationships(s)
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1 In the present study, CDDO-Me ameliorated monocyte infiltration without vasogenic edema formation in the frontoparietal cortex (FPC) following SE, accompanied by abrogating monocyte chemotactic protein-1 (MCP-1)/tumor necrosis factor-alpha (TNF-alpha) expressions and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation. bardoxolone methyl C-C motif chemokine ligand 2 Homo sapiens
2 In the present study, CDDO-Me ameliorated monocyte infiltration without vasogenic edema formation in the frontoparietal cortex (FPC) following SE, accompanied by abrogating monocyte chemotactic protein-1 (MCP-1)/tumor necrosis factor-alpha (TNF-alpha) expressions and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation. bardoxolone methyl C-C motif chemokine ligand 2 Homo sapiens
3 Therefore, these findings suggest, for the first time, that CDDO-Me may attenuate microglia/monocyte-mediated neuroinflammation via modulating NFkappaB- and p38 MAPK-MCP-1 signaling pathways following SE. bardoxolone methyl C-C motif chemokine ligand 2 Homo sapiens