Pub. Date : 2020 Apr 30
PMID : 32365859
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In peripheral tissues, exercise induced IL-6 can result in GLUT4 translocation and increased glucose uptake through AMPK activation. | Glucose | interleukin 6 | Homo sapiens |
| 2 | The aim of this study is to examine if IL-6 treatment: (1) results in AMPK activation in neuronal cells, (2) increases the activation of proteins involved in GLUT4 translocation, and (3) increases neuronal glucose uptake. | Glucose | interleukin 6 | Homo sapiens |
| 3 | Importantly, IL-6 treatment increased glucose uptake. | Glucose | interleukin 6 | Homo sapiens |
| 4 | Our findings demonstrate that IL-6 and insulin can phosphorylate AS160 via different signaling pathways (AMPK and PI3K/Akt, respectively) and promote GLUT4 translocation towards the neuronal plasma membrane, resulting in increased neuronal glucose uptake in SH-SY5Y cells. | Glucose | interleukin 6 | Homo sapiens |