Title : Differential RD-1-specific IFN-γ host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region.

Pub. Date : 2020 Jul

PMID : 32339714






2 Functional Relationships(s)
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1 METHODS: We evaluated the IFN-gamma responses (QuantiFERON-TB Gold-In-Tube (QFT-GIT) TSPOT-TB) stratified according to the M.tb spoligotype of the culture isolate obtained from the same patients with confirmed active TB (n = 91). Terbium interferon gamma Homo sapiens
2 RESULTS: In HIV uninfected patients TSPOT.TB and QFT-GIT IFN-gamma responses were 5-fold (p < 0.01) and 2-fold higher (p < 0.05) for those infected with family 33 compared to the LAM strain (additionally, TSPOT.TB responses were 5.6-fold (p < 0.05) and 2.6-fold higher (p < 0.05) for the patients infected with the family 33 versus the X strain and Beijing versus the LAM strain, respectively). Terbium interferon gamma Homo sapiens