Pub. Date : 2021 Jan
PMID : 32333821
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multidrug resistance protein 4 (MRP4/ABCC4) expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux. | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 2 | Multidrug resistance protein 4 (MRP4/ABCC4) expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux. | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 3 | Acting through histamine H2 receptors histamine increases cAMP production/synthesis, while MRP4/ABCC4 is responsible for the exclusion of this cyclic nucleotide. | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 4 | In this study, we show that histamine treatment induces MRP4/ABCC4 expression, augmenting cAMP efflux and that histamine, in combination with MRP inhibitors, is able to reduce AML cell proliferation. | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 5 | In this study, we show that histamine treatment induces MRP4/ABCC4 expression, augmenting cAMP efflux and that histamine, in combination with MRP inhibitors, is able to reduce AML cell proliferation. | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 6 | Histamine, through histamine H2 receptor, increases i-cAMP levels and induces MRP4 transcript and protein levels in U937, KG1a, and HL-60 cells. | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 7 | Moreover, histamine induces MRP4 promoter activity in HEK293T cells transfected with histamine H2 receptor (HEK293T-H2 R). | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 8 | Our results support that the cAMP/Epac-PKA pathway, and not MEK/ERK nor PI3K/AKT signaling cascades, is involved in histamine mediated upregulation of MRP4 levels. | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |
| 9 | Finally, the addition of histamine potentiates the inhibition of U937, KG1a, and HL-60 cell proliferation induced by MRP4 inhibitors. | Histamine | ATP binding cassette subfamily C member 4 | Homo sapiens |