Pub. Date : 2020 May
PMID : 32330868
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Importantly, Metformin reduced pyroptosis-related proteins, including NLRP3, cleaved caspase-1, and the N-terminus of GSDMD. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | We also discovered that Metformin suppressed the expression of TXNIP and the interaction between TXNIP and NLRP3. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | In conclusion, we believe that Metformin protects against intestinal I/R injury in a TXNIP-NLRP3-GSDMD-dependent manner. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |