Title : Cyclosporin A suppresses Porphyromonas gingivalis lipopolysaccharide induced matrix metalloproteinases activities in the co-culture of human gingival fibroblasts and monocyte cell line THP-1.

Pub. Date : 2020 Feb

PMID : 32321312






4 Functional Relationships(s)
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1 In the co-culture, we found that CsA inhibited the expression of cyclophilin A (CyPA), CD147 and the activities of MMPs, which were all induced by P.g-LPS. Cyclosporine peptidylprolyl isomerase A Homo sapiens
2 In the co-culture, we found that CsA inhibited the expression of cyclophilin A (CyPA), CD147 and the activities of MMPs, which were all induced by P.g-LPS. Cyclosporine peptidylprolyl isomerase A Homo sapiens
3 We also found that P.g-LPS and recombinant human CyPA increased activation of ERK1/2 and IkappaB (an NF-kappaB inhibitory protein), but CsA and the anti-CD147 antibody significantly inhibited these effects. Cyclosporine peptidylprolyl isomerase A Homo sapiens
4 Taken together, CsA in the presence of P.g-LPS might suppress MMP activities by blocking the CyPA/CD147 interaction that results in the inhibition of ERK1/2 and NF-kappaB signaling by interfering with the phosphorylation of ERK1/2 and IkappaB. Cyclosporine peptidylprolyl isomerase A Homo sapiens