Pub. Date : 2020 Feb
PMID : 32321312
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In the co-culture, we found that CsA inhibited the expression of cyclophilin A (CyPA), CD147 and the activities of MMPs, which were all induced by P.g-LPS. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
2 | In the co-culture, we found that CsA inhibited the expression of cyclophilin A (CyPA), CD147 and the activities of MMPs, which were all induced by P.g-LPS. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
3 | We also found that P.g-LPS and recombinant human CyPA increased activation of ERK1/2 and IkappaB (an NF-kappaB inhibitory protein), but CsA and the anti-CD147 antibody significantly inhibited these effects. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |
4 | Taken together, CsA in the presence of P.g-LPS might suppress MMP activities by blocking the CyPA/CD147 interaction that results in the inhibition of ERK1/2 and NF-kappaB signaling by interfering with the phosphorylation of ERK1/2 and IkappaB. | Cyclosporine | peptidylprolyl isomerase A | Homo sapiens |