Title : Improving Treatment Efficacy of In Situ Forming Implants via Concurrent Delivery of Chemotherapeutic and Chemosensitizer.

Pub. Date : 2020 Apr 20

PMID : 32313056






3 Functional Relationships(s)
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1 In this study, we have developed an ISFI capable of overcoming the Pgp resistance by co-delivering a chemotherapeutic, Doxorubicin (Dox), with a Pgp inhibitor, either Pluronic P85 or Valspodar (Val). valspodar phosphoglycolate phosphatase Mus musculus
2 In this study, we have developed an ISFI capable of overcoming the Pgp resistance by co-delivering a chemotherapeutic, Doxorubicin (Dox), with a Pgp inhibitor, either Pluronic P85 or Valspodar (Val). valspodar phosphoglycolate phosphatase Mus musculus
3 These findings demonstrate that co-delivery of Dox and Val via ISFI can avoid systemic toxicity issues seen with clinical Pgp inhibitors. valspodar phosphoglycolate phosphatase Mus musculus