Pub. Date : 2020 Jul
PMID : 32294462
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lactate enhances Arc/arg3.1 expression through hydroxycarboxylic acid receptor 1-beta-arrestin2 pathway in astrocytes. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 2 | In recent years, with the discovery and research of lactate-specific receptor HCAR1(hydroxycarboxylic acid receptor 1), lactate is not only as a product of Glycolysis in astrocytes, but also as a signaling molecule which has gradually received attention. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 3 | In recent years, with the discovery and research of lactate-specific receptor HCAR1(hydroxycarboxylic acid receptor 1), lactate is not only as a product of Glycolysis in astrocytes, but also as a signaling molecule which has gradually received attention. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 4 | In recent years, with the discovery and research of lactate-specific receptor HCAR1(hydroxycarboxylic acid receptor 1), lactate is not only as a product of Glycolysis in astrocytes, but also as a signaling molecule which has gradually received attention. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 5 | In recent years, with the discovery and research of lactate-specific receptor HCAR1(hydroxycarboxylic acid receptor 1), lactate is not only as a product of Glycolysis in astrocytes, but also as a signaling molecule which has gradually received attention. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 6 | Here, we focus on HCAR1 on the most widely distributed astrocytes in the brain, found and verified that lactate could cause Arc/arg3.1 protein overexpression in astrocytes through HCAR1. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 7 | Here, we focus on HCAR1 on the most widely distributed astrocytes in the brain, found and verified that lactate could cause Arc/arg3.1 protein overexpression in astrocytes through HCAR1. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 8 | However, the expression of Arc/arg3.1 does not depend on the Gi protein pathway of HCAR1, and we found that lactate enhanced the expression of Arc/arg3.1 protein through the HCAR1-beta-arrestin2 pathway. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |
| 9 | In summary, lactate acts on HCAR1 of astrocytes. | Lactic Acid | hydroxycarboxylic acid receptor 1 | Homo sapiens |