Title : Asymmetric Total Synthesis of (-)-Spirochensilide A.

Pub. Date : 2020 May 6

PMID : 32286815






1 Functional Relationships(s)
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1 The synthesis features a semi-pinacol rearrangement reaction to stereoselectively construct the two-vicinal quaternary chiral centers at C8 and C10, a tungsten-mediated cyclopropene-based Pauson-Khand reaction to install the C13 quaternary chiral center, and a furan-based oxidative cyclization to stereoselectively form the spiroketal motif. Tungsten homeobox C13 Homo sapiens