Pub. Date : 2015 May 7
PMID : 32262232
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Coumarin-benzothiazole-chlorambucil (Cou-Benz-Cbl) conjugate: an ESIPT based pH sensitive photoresponsive drug delivery system. | Chlorambucil | Cbl proto-oncogene | Homo sapiens |
| 2 | We have developed an ESIPT based drug delivery system (DDS), Cou-Benz-Cbl conjugate, by incorporating a benzothiazole group at the 8th position of the 7-hydroxy-coumarin moiety for pH sensitive fluorescence properties and photocontrolled release of the anticancer drug chlorambucil. | Chlorambucil | Cbl proto-oncogene | Homo sapiens |
| 3 | Photolysis of the Cou-Benz-Cbl conjugate using UV light of wavelength >=365 nm resulted in the efficient release of the anticancer drug chlorambucil. | Chlorambucil | Cbl proto-oncogene | Homo sapiens |
| 4 | Further, an MTT assay showed that the Cou-Benz-Cbl conjugate has a good biocompatibility and low cytotoxicity towards the MDA-MB-231 cell line, whereas upon exposure to UV light, the Cou-Benz-Cbl conjugate exhibited enhanced cytotoxicity compared to the free drug due to the effective release of the anticancer drug chlorambucil inside the cancer cell. | Chlorambucil | Cbl proto-oncogene | Homo sapiens |
| 5 | Further, an MTT assay showed that the Cou-Benz-Cbl conjugate has a good biocompatibility and low cytotoxicity towards the MDA-MB-231 cell line, whereas upon exposure to UV light, the Cou-Benz-Cbl conjugate exhibited enhanced cytotoxicity compared to the free drug due to the effective release of the anticancer drug chlorambucil inside the cancer cell. | Chlorambucil | Cbl proto-oncogene | Homo sapiens |