Title : Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate.

Pub. Date : 2020 Apr

PMID : 32256770






4 Functional Relationships(s)
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1 Effects of mevalonate kinase interference on cell differentiation, apoptosis, prenylation and geranylgeranylation of human keratinocytes are attenuated by farnesyl pyrophosphate or geranylgeranyl pyrophosphate. geranylgeranyl pyrophosphate mevalonate kinase Homo sapiens
2 Furthermore, the apoptotic rate was markedly increased following MVK interference, and the increase was significantly attenuated by GGPP. geranylgeranyl pyrophosphate mevalonate kinase Homo sapiens
3 The prenylation levels after MVK interference was notably decreased, which was markedly attenuated by GGPP. geranylgeranyl pyrophosphate mevalonate kinase Homo sapiens
4 FPP or GGPP reversed MVK interference-induced decrease in geranylgeranylation levels of lamin A, HRAS, KRAS, NRAS, Rho E, Rho B, Rho A, RAC1 and cdc42. geranylgeranyl pyrophosphate mevalonate kinase Homo sapiens