Title : 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers.

Pub. Date : 2020 Dec

PMID : 32253945






1 Functional Relationships(s)
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1 Two amide derivatives, displaying the best P-gp activity, were tested in co-administration with the antineoplastic drug doxorubicin in different cancer cell lines, showing a significant sensitising activity towards doxorubicin. Doxorubicin ATP binding cassette subfamily B member 1 Homo sapiens