Title : Hypertension following intrathecal injection of cholinergic agonists in conscious rats: role of endogenous acetylcholine.

Pub. Date : 1988 Nov

PMID : 3225383






1 Functional Relationships(s)
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1 injection of neostigmine (1-10 micrograms) elicited a dose-related increase in mean arterial pressure of up to 45 mm Hg which remained elevated for almost 2 h. Significant inhibition of acetylcholinesterase was localized to the spinal cord, with the thoracic region exhibiting the greatest degree of inhibition. Neostigmine acetylcholinesterase Rattus norvegicus