Title : Tumor Responsive and Tunable Polymeric Platform for Optimized Delivery of Paclitaxel to Treat Glioblastoma.

Pub. Date : 2020 Apr 29

PMID : 32252517






2 Functional Relationships(s)
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1 Scaffolds composed of fast, medium, and slow degrading Ace-DEX resulted in 14.1%, 2.9%, and 1.3% paclitaxel released per day. Paclitaxel angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus
2 Additionally, the acid-sensitive Ace-DEX scaffolds were shown to respond to the lower pH conditions associated with GBM tumors, releasing more paclitaxel in vivo when a tumor was present in contrast to nonacid sensitive PLA scaffolds. Paclitaxel angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus