Title : Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by β-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention.

Pub. Date : 2020 Apr 2

PMID : 32252311






3 Functional Relationships(s)
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1 Modulation of STAT3 Signaling, Cell Redox Defenses and Cell Cycle Checkpoints by beta-Caryophyllene in Cholangiocarcinoma Cells: Possible Mechanisms Accounting for Doxorubicin Chemosensitization and Chemoprevention. caryophyllene signal transducer and activator of transcription 3 Homo sapiens
2 A lowered expression of doxorubicin-induced STAT3 activation was found in the presence of beta-caryophyllene in both cancer and normal cholangiocytes. caryophyllene signal transducer and activator of transcription 3 Homo sapiens
3 This evidence highlighted a possible role of STAT3 as a final effector of a complex network regulated by beta-caryophyllene, which leads to an enhanced doxorubicin-sensitivity of cholangiocarcinoma cells and a lowered chemotherapy toxicity in nonmalignant cholangiocytes, thus strengthening the interest for this natural sesquiterpene as a dual-acting chemosensitizing and chemopreventive agent. caryophyllene signal transducer and activator of transcription 3 Homo sapiens