Title : Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway.

Pub. Date : 2020 Jul

PMID : 32251678






3 Functional Relationships(s)
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1 Loratadine also specifically inhibited the NF-kB pathway, targeting the Syk and Src proteins. Loratadine spleen tyrosine kinase Mus musculus
2 Furthermore, loratadine bound Src in the bridge between SH2 and SH3, and bound Syk in the protein tyrosine kinase domain. Loratadine spleen tyrosine kinase Mus musculus
3 Taken together, loratadine inhibited the inflammatory response through the NF-kB pathway by binding with the Syk and Src proteins. Loratadine spleen tyrosine kinase Mus musculus