Title : Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer.

Pub. Date : 2020 May 13

PMID : 32250633






2 Functional Relationships(s)
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1 Upon blue light irradiation (430 nm), CNPPtCP/si(c-fos) could generate oxygen-independent N3 with mild oxidation energy for efficient endo/lysosomal escape through N3 -assisted photochemical internalization with less gene deactivation. Silicon Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Both in vitro and in vivo results demonstrated that CNPPtCP/si(c-fos) displayed excellent synergistic therapeutic efficacy on PROC with low toxicity. Silicon Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens