Title : Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress-Induced Intestinal Environment Imbalance and Lipopolysaccharide-Induced Liver Injury in HFD-Fed Rats by Regulating the Nrf2/HO-1/NQO1 and MAPK Pathways.

Pub. Date : 2020 May

PMID : 32250024






1 Functional Relationships(s)
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1 In the colon, treatment with LCP for 8 weeks ameliorated enhanced intestinal permeability (GLP-2 content and occludin protein increased, whereas claudin-2 protein decreased), intestinal inflammation (levels of pro-inflammatory cytokines, such as TNF-alpha, IL-6, COX-2, and NF-kappaB p65, decreased), and intestinal OSD (through regulation of the Nrf2/HO-1/NQO1 pathway). Perchloric Acid tumor necrosis factor Rattus norvegicus