Pub. Date : 2020
PMID : 32238696
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pro-apoptotic functions of TRAF2 in p53-mediated apoptosis induced by cisplatin. | Cisplatin | tumor protein p53 | Homo sapiens |
| 2 | In this study, we assessed the function of TRAF2 in DDR induced by cisplatin, a representative DNA-damaging agent, and found that TRAF2 exerts pro-apoptotic activity through p53-dependent mechanisms at least in human fibrosarcoma cell line HT1080. | Cisplatin | tumor protein p53 | Homo sapiens |
| 3 | Moreover, cisplatin-induced JNK activation was attenuated in TRAF2-deficient cells, and pharmacological inhibition of JNK signaling suppressed p53 stabilization. | Cisplatin | tumor protein p53 | Homo sapiens |