Title : Effective Recognition of Caffeine by Diaminocarbazolic Receptors.

Pub. Date : 2020 Jul

PMID : 32237230






1 Functional Relationships(s)
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1 Herein, we describe two structurally related and readily available artificial receptors: 1) a macrocyclic receptor, which binds caffeine with the unprecedented affinity of 9.3 muM, though with poor selectivity; and 2) a tweezers-like structure, showing an affinity of 26 muM and a 4.5-fold and 6-fold selectivity toward theophylline and theobromine, respectively. Theophylline latexin Homo sapiens