Title : Mitochondrial superoxide mediates PM2.5-induced cytotoxicity in human pulmonary lymphatic endothelial cells.

Pub. Date : 2020 Aug

PMID : 32222623






1 Functional Relationships(s)
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1 Mechanistically, we provide compelling evidence that PM2.5 reduces SOD2 expression through activation of Akt pathway, which leads to a disruption of mitochondrial redox homeostasis characterized by increased accumulation of mitochondrial superoxide. Superoxides superoxide dismutase 2 Homo sapiens