Title : Immunoglobulins from patients with amyotrophic lateral sclerosis affect human erythrocyte acetylcholinesterase.

Pub. Date : 1988 Sep

PMID : 3221239






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Human erythrocyte acetylcholinesterase (AChE) solubilized with Triton X-100 and obtained as a complex with micelles containing Triton and membrane phospholipids was incubated with immunoglobulins (Igs) from patients with amyotrophic lateral sclerosis (ALS) and from normal individuals. Phospholipids acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Human erythrocyte acetylcholinesterase (AChE) solubilized with Triton X-100 and obtained as a complex with micelles containing Triton and membrane phospholipids was incubated with immunoglobulins (Igs) from patients with amyotrophic lateral sclerosis (ALS) and from normal individuals. Phospholipids acetylcholinesterase (Cartwright blood group) Homo sapiens
3 At least part of the autoantibodies should be directed against the enzyme molecule, since a change in the Arrhenius plot was also observed in a control experiment with AChE which probably had micelles without any phospholipids. Phospholipids acetylcholinesterase (Cartwright blood group) Homo sapiens
4 This enzyme was isolated by affinity chromatography and was washed with a buffer containing Triton X-100 before desorption from the affinity column, a treatment known to remove all phospholipids from erythrocyte AChE. Phospholipids acetylcholinesterase (Cartwright blood group) Homo sapiens