Title : Bi-allelic LoF NRROS Variants Impairing Active TGF-β1 Delivery Cause a Severe Infantile-Onset Neurodegenerative Condition with Intracranial Calcification.

Pub. Date : 2020 Apr 2

PMID : 32197075






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Negative regulator of reactive oxygen species (NRROS) is a leucine-rich repeat-containing protein that uniquely associates with latent transforming growth factor beta-1 (TGF- beta1) and anchors it on the cell surface; this anchoring is required for activation of TGF-beta1 in macrophages and microglia. Leucine transforming growth factor beta 1 Homo sapiens
2 Negative regulator of reactive oxygen species (NRROS) is a leucine-rich repeat-containing protein that uniquely associates with latent transforming growth factor beta-1 (TGF- beta1) and anchors it on the cell surface; this anchoring is required for activation of TGF-beta1 in macrophages and microglia. Leucine transforming growth factor beta 1 Homo sapiens
3 Negative regulator of reactive oxygen species (NRROS) is a leucine-rich repeat-containing protein that uniquely associates with latent transforming growth factor beta-1 (TGF- beta1) and anchors it on the cell surface; this anchoring is required for activation of TGF-beta1 in macrophages and microglia. Leucine transforming growth factor beta 1 Homo sapiens