Title : BRD4 Inhibition by AZD5153 Promotes Antitumor Immunity via Depolarizing M2 Macrophages.

Pub. Date : 2020

PMID : 32184777






2 Functional Relationships(s)
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1 Importantly, the 3-D microfluid model demonstrates that AZD5153 sensitizes ovarian cancer to anti-PD-L1 therapy. AZD5153 CD274 molecule Homo sapiens
2 Our results clarify that besides eliminating tumor cells directly, AZD5153 works as a regulator of the TAM phenotype, providing a novel strategy combining AZD5153 and PD-1/PD-L1 antibody that could benefit HGSOC patients. AZD5153 CD274 molecule Homo sapiens