Title : Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo.

Pub. Date : 2020 Dec

PMID : 32180132






1 Functional Relationships(s)
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1 IFN-gamma potently enhanced TNFA, IL12, HLADRA1 and LRRK2 expression, which was suppressed by FK506, a calcineurin-specific inhibitor, but further enhanced by LRRK2-specific kinase inhibitor (GSK2578215A). Tacrolimus tumor necrosis factor Homo sapiens