Title : Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency.

Pub. Date : 2020 Mar 16

PMID : 32178712






5 Functional Relationships(s)
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Protein Name
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1 Combining G418 with a PTC readthrough enhancer increased PGRN levels over G418 treatment alone in vitro. antibiotic G 418 granulin Mus musculus
2 Combining G418 with a PTC readthrough enhancer increased PGRN levels over G418 treatment alone in vitro. antibiotic G 418 granulin Mus musculus
3 Increasing PGRN through G418-mediated PTC readthrough normalized this abnormal lysosomal phenotype in R493X-/- KI neuronal cultures. antibiotic G 418 granulin Mus musculus
4 A single intracerebroventricular injection of G418 induced GRN PTC readthrough in 6-week-old AAV-GRN-R493X-V5 mice. antibiotic G 418 granulin Mus musculus
5 A single intracerebroventricular injection of G418 induced GRN PTC readthrough in 6-week-old AAV-GRN-R493X-V5 mice. antibiotic G 418 granulin Mus musculus