Title : CK2 Inhibition Prior to Status Epilepticus Persistently Enhances KCa2 Function in CA1 Which Slows Down Disease Progression.

Pub. Date : 2020

PMID : 32174814






4 Functional Relationships(s)
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1 Previously, we observed that in vivo casein kinase 2 (CK2) inhibition with 4,5,6,7-tetrabromotriazole (TBB) had anti-epileptogenic effects in the acute epilepsy slice model. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate casein kinase 2 beta Rattus norvegicus
2 Previously, we observed that in vivo casein kinase 2 (CK2) inhibition with 4,5,6,7-tetrabromotriazole (TBB) had anti-epileptogenic effects in the acute epilepsy slice model. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate casein kinase 2 beta Rattus norvegicus
3 Western blot analyses demonstrated that CA1 tissue from TBB-pretreated epileptic animals contained significantly less CK2 than TBB-pretreated controls. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate casein kinase 2 beta Rattus norvegicus
4 Conclusion: These data indicate that TBB pretreatment prior to SE slows down disease progression during epileptogenesis involving increased KCa2 function, probably due to a persistently decreased CK2 protein expression. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate casein kinase 2 beta Rattus norvegicus