Title : Convulsive responses to seizure-inducible drugs are exacerbated in progranulin-deficient mice.

Pub. Date : 2020 Apr 8

PMID : 32168097






3 Functional Relationships(s)
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1 First, we treated wild type and PGRN-deficient mice with seizure-inducible drugs, bicuculline or N-methyl-D-aspartate (NMDA), which provoke hyperexcitement of neurons. N-Methylaspartate granulin Mus musculus
2 First, we treated wild type and PGRN-deficient mice with seizure-inducible drugs, bicuculline or N-methyl-D-aspartate (NMDA), which provoke hyperexcitement of neurons. N-Methylaspartate granulin Mus musculus
3 PGRN-deficient mice showed higher intensity of seizure and longer duration of convulsive behavior when treated with either bicuculline or NMDA. N-Methylaspartate granulin Mus musculus