Title : Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in mice.

Pub. Date : 2020 Mar 10

PMID : 32157166






1 Functional Relationships(s)
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1 Analysis of isolated tubular epithelia by FACS from bigenic SLC34a1-CreERt2; R26tdTomato proximal tubular-specific reporter mice revealed that KU55933 upregulated p53 and subsequent pro-apoptotic signaling in tubular epithelia of cisplatin-treated mice, leading to marked mitochondrial injury and apoptosis. 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one acyl-CoA synthetase long-chain family member 1 Mus musculus