Title : Theobromine mitigates IL-1β-induced oxidative stress, inflammatory response, and degradation of type II collagen in human chondrocytes.

Pub. Date : 2020 Mar 5

PMID : 32146317






1 Functional Relationships(s)
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1 Mechanistically, we show that theobromine inhibits IL-1beta-induced IkappaBalpha activation, nuclear factor-kappaB (NF-kappaB) protein p65 accumulation, and transfected NF-kappaB promoter activity, indicating that theobromine suppresses the NF-kappaB pathway in chondrocytes. Theobromine RELA proto-oncogene, NF-kB subunit Homo sapiens