Title : Pathogenic PTPN11 variants involving the poly-glutamine Gln255 -Gln256 -Gln257 stretch highlight the relevance of helix B in SHP2's functional regulation.

Pub. Date : 2020 Jun

PMID : 32112654






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Pathogenic PTPN11 variants involving the poly-glutamine Gln255 -Gln256 -Gln257 stretch highlight the relevance of helix B in SHP2"s functional regulation. polyglutamine protein tyrosine phosphatase non-receptor type 11 Homo sapiens
2 Pathogenic PTPN11 variants involving the poly-glutamine Gln255 -Gln256 -Gln257 stretch highlight the relevance of helix B in SHP2"s functional regulation. polyglutamine protein tyrosine phosphatase non-receptor type 11 Homo sapiens
3 This poly-glutamine stretch is located on helix B of the PTP domain, a region involved in stabilizing SHP2 in its autoinhibited state. polyglutamine protein tyrosine phosphatase non-receptor type 11 Homo sapiens