Pub. Date : 2020 Jun
PMID : 32112654
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Pathogenic PTPN11 variants involving the poly-glutamine Gln255 -Gln256 -Gln257 stretch highlight the relevance of helix B in SHP2"s functional regulation. | polyglutamine | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
2 | Pathogenic PTPN11 variants involving the poly-glutamine Gln255 -Gln256 -Gln257 stretch highlight the relevance of helix B in SHP2"s functional regulation. | polyglutamine | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
3 | This poly-glutamine stretch is located on helix B of the PTP domain, a region involved in stabilizing SHP2 in its autoinhibited state. | polyglutamine | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |