Pub. Date : 2020 Feb 26
PMID : 32111081
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | Several studies reported that in contrast with the wild type protein, mutant p53 isoforms fail to exert antioxidant activities and rather increase intracellular ROS, driving a pro-tumorigenic survival. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | These pro-oxidant oncogenic abilities of GOF mutant p53 include signaling and metabolic rewiring, as well as the modulation of critical ROS-related transcription factors and antioxidant systems, which lead ROS unbalance linked to tumor progression. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | These pro-oxidant oncogenic abilities of GOF mutant p53 include signaling and metabolic rewiring, as well as the modulation of critical ROS-related transcription factors and antioxidant systems, which lead ROS unbalance linked to tumor progression. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 5 | The studies summarized here highlight that GOF mutant p53 isoforms might constitute major targets for selective therapeutic intervention against several types of tumors and that ROS enhancement driven by mutant p53 might represent an "Achilles heel" of cancer cells, suggesting pro-oxidant drugs as a therapeutic approach for cancer patients bearing the mutant TP53 gene. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |