Pub. Date : 2020 Mar 27
PMID : 32110810
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 2-phenylethynesulfonamide inhibits growth of oral squamous cell carcinoma cells by blocking the function of heat shock protein 70. | 2-phenylacetylenesulfonamide | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 2 | 2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed to be less toxic to normal cells. | 2-phenylacetylenesulfonamide | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 3 | 2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed to be less toxic to normal cells. | 2-phenylacetylenesulfonamide | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 4 | 2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed to be less toxic to normal cells. | 2-phenylacetylenesulfonamide | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 5 | 2-phenylethynesulfonamide (PES) was known as a selective heat shock protein 70 (Hsp70) function inhibitor, which induced cytotoxic effects on various tumor cell types, but showed to be less toxic to normal cells. | 2-phenylacetylenesulfonamide | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 6 | Additionally, knockdown of Hsp70 enhanced the effects of PES. | 2-phenylacetylenesulfonamide | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 7 | In conclusion, the present study demonstrated that PES suppresses the growth of OSCC cells through Hsp70-dependent mechanism. | 2-phenylacetylenesulfonamide | heat shock protein family A (Hsp70) member 4 | Homo sapiens |