Title : All-trans retinoic acid regulates TGF-β1-induced extracellular matrix production via p38, JNK, and NF-κB-signaling pathways in nasal polyp-derived fibroblasts.

Pub. Date : 2020 May

PMID : 32104972






4 Functional Relationships(s)
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1 All-trans retinoic acid regulates TGF-beta1-induced extracellular matrix production via p38, JNK, and NF-kappaB-signaling pathways in nasal polyp-derived fibroblasts. Tretinoin transforming growth factor beta 1 Homo sapiens
2 TGF-beta1-induced fibroblasts were pretreated with ATRA. Tretinoin transforming growth factor beta 1 Homo sapiens
3 TGF-beta1-induced cell migration and collagen gel contraction were significantly inhibited by ATRA pretreatment. Tretinoin transforming growth factor beta 1 Homo sapiens
4 ATRA also significantly inhibited phosphorylation of c-Jun N-terminal kinase (JNK), p38, and p50 in TGF-beta1-induced NPDFs, but did not inhibit phosphorylation of extracellular signal-related kinase (ERK). Tretinoin transforming growth factor beta 1 Homo sapiens